From Dushanbe: Airplane usually flies 1 flight a day, when the weather is good during the summer. Spectacular flight, for about USD 85.
Vehicles run constantly to Khorugh. Best to get there is very early in the morning, maybe 6-7AM. Vehicles leave from a secret lot, tucked away near the airport. Most people in the capital are unaware of its location. When heading to the airport from the north you go into a dip going under a big road. Just before that there will be a dead end road on your right. Get out of the car and walk through a big gate lots of people heading that way, though. Just repeat "Khorogh" to everyone, and sooner or later someone will know what you're talking about. Price is anywhere from USD 40-60, depending on the vehicle.
Get a good vehicle. A good vehicle usually means a good driver. The trip takes between 15hours to two days.
